The map is smaller than most farming areas, however this is the benefit of the zone D2R ladder items buy. It's easy to clear by only one person and every square inch is filled with profitable equipment and treasures. After a successful run, reset the game and repeat.
River of Flame (Act 4)Moving into Act 4, there aren't many waypoints in the area. It makes finding farming spot preferred spots a bit more difficult. That's why the majority of players go to The River of Flame as both a gold mine and a gauntlet to see whether their players have the skills to weather some of the most challenging encounters.
River of Flame has clustered monsters and lava that only a Barbarian with Leap or an Sorceress with Teleport abilities can utilize to their advantage. To top it all off, Hephasto the Armor is always itching to take down the players. If they manage to conquer these challenges, they'll be rewarded handsomely.
Chaos Sanctuary a.k.a. Diablo Run (Act 4)In the event that they don't gain something significant or valuable at the River of Flame, players have the option of moving on to the next large area, which is Diablo's mainhold, Chaos Sanctuary Best place to buy D2R items. In addition, it houses some of the strongest and generous enemies of the game.